T. Nishimura, K. Nakano, S. Shibamoto
Jun 1, 1975
Citations
0
Influential Citations
7
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The reaction of 1-phenyl-1,2-propanedione with 1,1-disubstituted guanidines in methanol yielded 2-(disubstituted amino)-4-hydroxy-4-methyl-4H-imidazoles (III). Compound III produced 5(4)methylimidazoles by catalytic hydrogenation and 5(4)chloromethylimidazoles (IV) by concentrated hydrochloric acid treatment. Solvolysis of IV in water and alcohols gave 5(4)hydroxymethyl- and 5(4)alkoxymethylimidazoles, respectively.