F. F. Van Leeuwen, A. Noordam, Leendert Maat
2010
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0
Influential Citations
2
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
Reaction of (−)-(S)-methyl 2-bromopropionate (4) (obtained from l-alanine) with dibenzyl ethylmalonate gave stereospecifically in four steps ( + )-(2R,3S)-2-ethyl-3-methylsuccinic acid (8a) and its diastereoisomer (8b). The malonic ester alkylation proceeded with Walden inversion. The chiroptical properties of the acids and the intermediates are in conformity with the known absolute configurations.