Ou Chun
2003
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Journal
Chemical Reagents
Abstract
2-Ethyl-4, 6-dihydroxypyrimidine was synthesized , with propionitrile as starting material, by reacting with hydrogen chloride and free ammonia, then in the presence of sodium methoxide by means of cyclization of diethyl malonuric esters with propionamide hydrochloride in 86% yield. The structures of these compounds were confirmed by MS and melting point. Their purity was better than 98%, analyzed by LC. The optimum conditions for synthesizing propionamide hydrochloride were exclusion of moisture and keeping the reaction temperature at -10 - 0℃, when hydrogen chloride gas was led in, its yield was 94. 0%.