Zhao Haoyu, Zhang Qimeng, J. Tao
2010
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Chemical Reagents
Abstract
2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material,through carboxyl group protection,introduction of iodine ions via diazotization,iodosubstitution and deprotection.The purity of the title compound(identified by HPLC) and total product yield was 99.819% and 54.51%,respectively.The structure of the product was confirmed by MS and 1HNMR.This manufacture process has a lot of advantages,such as the low production costs,the mild reaction conditions,and being readily realizable in commercial scale.A patent has been filed on this production method.