M. Brugger, S. Borges, S. Ren
Dec 1, 2010
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
An efficient synthesis of [2H4] and [14C]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [2H4]oxymetazoline from [2H4]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [14C]oxymetazoline from potassium [14C]cyanide was achieved in two steps with an overall radiochemical yield of 67%. Copyright © 2010 John Wiley & Sons, Ltd.