Zhang Dan-shen
2009
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Journal
Journal of Hebei North University
Abstract
To synthesize 2-methyl-2-[4-(2-oxo-2-(pyrrolidin-1-yl) ethyl) phenoxy] propanoic acid.2-(4-hydroxyphenyl)acetic acid reacted with thionyl chloride to produce 2-(4-hydroxyphenyl)acetyl chloride.2-methyl-2-[4-(2-oxo-2-(pyrrolidin-1-yl) ethyl) phenoxy] propanoic acid was synthesized from 2-(4-hydroxyphenyl) acetyl chloride by condensation with Pyrrolidine to give 2-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl)ethanone,which was subjected to reaction with acetone,chloroform and NaOH.2-methyl-2-[4-(2-oxo-2-(pyrrolidin-1-yl) ethyl) phenoxy] propanoic acid was synthesized with the overall yield about 38%.The target compound had been confirmed by IR,1HNmR and MS.