V. Sosnovskikh, B. Usachev
Nov 1, 2002
Citations
0
Influential Citations
9
Citations
Journal
Synthesis
Abstract
N-Benzyl-2-trifluoroimethyl -4H-chromen-4-imines and malonic acid on heating in anhydrous dioxane afford 2-trifluoromethyl-2-methylchroman-4-ones in ∼60% yield. 2-Methyl-2-trifluoromethyl-4-oxochromane-6-carbaldehyde and 2-methyl-2-trifluoromethyl-4-oxochromane-6-carboxylic acid, the fluorinated analogues of natural lactarochromal and the corresponding acid, were obtained by the oxidation of 2,6-dimethyl-2-trifluoromethyl-chroman-4-one with K 2 S 2 O 8 .