Xiong Li-li
2007
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Journal
Fine Chemical Intermediates
Abstract
The compound 2-methylthio-4,6-difluoride pyrimidine was an important intermediate of herbicide diclosulam. 2-methylthio-4,6-difluoride pyrimidine was synthesized through four step veactions from sulfocarbamidediethyl malonate,sodium methanol,dimethyl sulphate,phosphorus oxychloride and potassium fluoride. The major factors that influenced the reactions were studied. The yield and purity of the product was 56% and 90% respectively,suggesting that the synthesis method had advantages of facile reaction conditions convenient operation and cheap reagents.