E. Pelkey, G. Gribble
Aug 11, 1997
Citations
0
Influential Citations
60
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A three-step sequence has been developed for converting o -nitrobenzaldehydes into 2-nitroindoles. The key step involves the thermolysis of 2-( o -azidophenyl)nitroethylene ( 10 ) in xylenes which gives 2-nitroindole ( 4 ) in 54% yield, akin to the classic Sundberg indole synthesis. This procedure has also been utilized to synthesize 5,6-dimethoxy-2-nitroindole ( 14 ).