J. J. D'amico, F. G. Bollinger
Jul 1, 1988
Citations
0
Influential Citations
12
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The reaction of 2-oxo-3-benzothiazolineacetic acid (5) and the 5-chloro analogue 6 with thionyl chloride afforded the titled compounds 7 and 8. The reaction of 7 or 8 with substituted hydrazines, amines or substituted anilines, alcohols and mercaptans furnished the hydrazides 9–14, acetamides and acetanilides 16–21, esters 26–30 and thiolesters 31–37, respectively. Alternate routes for the synthesis of hydrazide 15, acetamides and acetanilides 22–25 and thiolesters 35–36 are described. The reaction of 2-oxo-3(2H)-benzothi-azolineacetonitrile with thioacetic acid under acidic conditions afforded 2-oxo-3-benzothiazolineethanethio-amide (38).