Guo Bao-guo
2012
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0
Influential Citations
1
Citations
Journal
Chemical Research and Application
Abstract
2-phenyl(4-pyrrolidinylethoxyphenyl)ethan-1-one was important structural fragments of antiosteoporosis drug Lasofoxifene.The intermediate was prepared by etherification,esterification with tosyl chloride in a simple and efficient step from phenol,and then the title compound was obtained by nucleophilic substitution and Friedel-Crafts acylation reaction in high yield.The chemical structure of the compound was characterized by NMR and HRMS.