Xuan Yun
2003
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2-Phenylpiperazine, an intermediate of mirtazapine was synthesized from phenylacetic acid by reaction with phosphorus trichloride and bromine to give ethyl α-bromophenylacetate which reacted with ethylenediamine followed by reduction with lithium aluminum hydride. The overall yield was 31.7%.