A. Solladié-Cavallo*, N. Khiar
Jul 1, 1990
Citations
0
Influential Citations
19
Citations
Journal
Journal of Organic Chemistry
Abstract
Natural(2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid is synthesized in 53-55% yield (referred to (−)-8-phenylmenthol used as chiral auxiliary) by condensation of 1-nitro-3-methylbutane on (−)-8-phenylmenthol glyoxylate hydrate using KF as a mild base. With a large excess of KF in THF it has been possible to increase the diastereoselectivity of the nitro aldol condensation