K. Makino, Eri Nagata, Y. Hamada
Nov 21, 2005
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
(2S,3R)-3-Hydroxy-3-methylproline, a constituent of cyclodepsipeptides polyoxypeptins A and B, was efficiently synthesized by lithium chloride-induced diastereoselective tandem Michael-aldol reaction using methyl vinyl ketone and N-1-naphthylsulfonylglycine (R)-binaphthyl ester and subsequent hydrolysis of the product in 39% overall yield and five steps.