Z. Gu, Xiao Lin, D. Hesson
Sep 7, 1995
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Influential Citations
4
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Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract (2S,4R)-4-Methylglutamic acid, a high affinity (IC50 = 35 nM) and selective ligand for the kainate (KA) receptor subtype, has been synthesized in multi-gram quantities starting from (S)-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethylpyrrolidine-2-2-one. The diastereoselective methylation step provides the required trans product in 47% isolated yield.