Ken‐ichi Tanaka, H. Sawanishi
Jan 16, 1998
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0
Influential Citations
20
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract An efficient and stereospecific synthesis of (2S,4S)-2,4-diaminoglutaric acid 1 starting from trans-4-hydroxy- l -proline 2 is presented. The key step involves the combined application of ruthenium tetroxide (RuO4) oxidation of 4-(tert-butoxycarbonylamino)proline derivatives 7 and 8 followed by regioselective ring opening of the resulting lactams 9 and 10 with 1 M LiOH.