P. Botman, F. Dommerholt, R. de Gelder
Nov 23, 2004
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0
Influential Citations
37
Citations
Journal
Organic letters
Abstract
[reaction: see text] Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in the synthetic sequence is a novel highly diastereoselective epoxidation reaction of an enantiomerically pure cyclic enamide intermediate.