Moumita Rakshit, Taraknath Kundu, G. Kar
May 1, 2013
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0
Influential Citations
3
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Journal
Monatshefte für Chemie - Chemical Monthly
Abstract
A number of 2-substituted 3,6-dihydropyrrolo[3,2-e]indoles were synthesised efficiently by the reaction of 4-iodo-1-(phenylsulfonyl)-5-(trifluoroacetamido)indole with terminal acetylenes in the presence of a palladium(0) catalyst and a copper(I) co-catalyst. The reaction involved one-pot Sonogashira coupling/heteroannulation, the first one of its kind in the synthesis of the title compounds. The required amido-iodoindole was prepared smoothly from 5-nitroindole by successive N-protection, reduction of the nitroarene, iodination of the resulting aminoarene and N-trifluoroacetylation.Graphical abstract