N. Franceschini, S. Nascimento, P. Sonnet
Oct 31, 2003
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron-asymmetry
Abstract
The synthesis of enantiomerically pure 4-(2-hydroxy-(1R)-phenylethyl)-thiomorpholin-3-one 2 from (R)-phenylglycine methyl ester, S-benzylthioglycolic acid and bromoacetic acid is reported. Stereoselective C-2 alkylation of 2, performed using various electrophiles, leads to enantiomerically pure 2-substituted thiomorpholin-3-ones after N-deprotection.