Q. Feng
2007
Citations
0
Influential Citations
0
Citations
Journal
Chemistry & Bioengineering
Abstract
2-Thiophene acetic acid was synthesized through the following steps.2-Acetylthiophene was condensed with an excess of n-butylamine in the presence of catalyst so as to obtain acetylthiophene-N-n-butylamine.The concentrated imine was reacted with excess sulfur in organic solvent to produce N-butylthioamide.After concentration,depositing,filtration, the thioamide was hydrolyzed by the action of NaOH in heptanol and acidificated ulteriorly to liberate 2-thiophene acetic acid.The total yield of 2-thiophene acid was 46.5%.