Zhong Guang-xiang, Chen Zuozuo, Zhou Cheng-cheng
2010
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Synthetic Chemistry
Abstract
2-Thiouracil was synthesized by one-pot method.The yield could reach 54.7% under the optimum reaction conditions.Thiourea was 33 mmol.n(ethyl acetate) ∶n(sodium methoxide) ∶n(ethyl formate) ∶n(thiourea) was 2.5 ∶2.0 ∶1.5 ∶1.0.Ethyl acetate reacted with sodium methoxide in 35 mL toluene at 80 ℃ for 3 h,then ethyl formate was added dropwise at 25 ℃,and thiourea in 10 mL alcohol was added after stirring at 25 ℃ for 8 h,followed by refluxing for 3 h.