G. Chaume, O. Barbeau, P. Lesot
May 19, 2010
Citations
0
Influential Citations
37
Citations
Journal
The Journal of organic chemistry
Abstract
Trifluoromethyl group containing oxazolidines (Fox) are conveniently synthesized by condensation of serine esters with trifluoroacetaldehyde hemiacetal or trifluoroacetone. These oxazolidines can undergo N-acylation and amidification reactions and are completely configurationally and hydrolytically stable. Therefore, they can be considered as highly valuable proline surrogates (Tfm-pseudoprolines).