Y. Gong, Katsuya Kato
May 1, 2004
Citations
0
Influential Citations
19
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract N-(1-Ethoxy-2,2,2-trifluoroethyl)anilines 2a–2f, prepared from trifluoroacetaldehyde ethyl hemiacetal and aniline, readily reacted with diethyl malonate in the presence of sodium hydride, giving substituted products 5a–5f in high yields. Compounds 5a–5f subjected to hydrolysis and decarboxylation under specified conditions yielded the 4,4,4-trifluorobutyric acids 6a–6e or 7. Direct ring-closure of 6a–6e with polyphosphoric acid gave 2-trifluoromethyl-2,3-dihydro-1H-quinolin-4-ones 9a–9e.