L. Kiss, Humberto S. Ferreira, D. Learmonth
Apr 10, 2008
Citations
0
Influential Citations
33
Citations
Journal
Organic letters
Abstract
Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide.