Anita Andicsová-Eckstein, E. Kozma, D. Végh
Nov 1, 2016
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0
Influential Citations
2
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A simple and efficient method for the synthesis of 3-oxopropanenitriles from variously substituted heterocyclic compounds via direct electrophilic cyanoacetylation is described. A series of heterocyclic 3-oxopropanenitriles (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k) have been synthesized using mixed anhydride (acetic or trifluoroacetic anhydride:cyanoacetic acid) in the presence of Mg(ClO4)2·2H2O as catalyst. This method can be extended also for the cyanoacetylation of electron poor aromatic compounds.