S. Sukdolak, N. Vukovic, S. Solujic
2006
Citations
0
Influential Citations
3
Citations
Journal
Journal of The Serbian Chemical Society
Abstract
Aminothiazole derivatives of 4-hydroxy-2H-chromen-2-one were prepared by the Hantzsch reaction 1 using 3-(2-bromoacetyl)-4-hydroxy-2H-chromen-2-one and thiourea derivatives. Starting compound for this synthesis 3-(2-bromoacetyl)-4-hydro- xy-2H-chromen-2-one (1) was prepared previously. 2 Also, for this synthesis we used thiourea derivatives (2a-j) as compounds which possess groups with biological activity. Reactions are carried out in refluxing ethanol for a period of 30 - 45 min. Final products (3a-j) are obtained in a high yield. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR and 1 H NMR spectroscopy).