H. Juan
2004
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Journal
West China Journal of Pharmaceutical Sciences
Abstract
OBJECTIVE To synthesize 3,3-bis(dibenzyloxyphosphoryl)propionic acid(5) and 3,3-bis(dibenzyloxyphosphoryl)propanol(6).METHODS 3,3-bis(dibenzyloxyphosphoryl) propionic acid (5) and (6) were synthesized from tetraethyl methylene bisphosphonate via hydrolysis,chlorination of the acid,esterification,condensation,then 3,3-bis (dibenzyloxyphosphoryl)propanol (6) was obtained via selective reduction of (5).RESULTS The structure of compounds (5) and (6) were confirmed by IR, 1HNMR and MS.CONCLUSION This method is a better method to synthesize compounds (5) and (6).