Z. Fang, Yunlong Song, T. Sarkar
May 1, 2008
Citations
0
Influential Citations
17
Citations
Journal
The Journal of organic chemistry
Abstract
A series of 3,3-diarylacrylonitriles were synthesized stereoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3,3-diarylacrylonitriles to be prepared in a very short sequence of reactions.