R. Nandi, R. Guillot, C. Kouklovsky
Mar 25, 2016
Citations
0
Influential Citations
37
Citations
Journal
Organic letters
Abstract
We report the cyclization of 3-substituted N-acetylindoles for the straightforward synthesis of 3,3-spiroindolines via the Friedel-Crafts reaction of an appended aryl group or the formal [2 + 2] cycloaddition of an appended alkene. Our strategy involves an Umpolung of the C2═C3 bond of the indole nucleus during FeCl3-mediated hydroarylation or annulation reactions.