Sheng Wenbing
2011
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Journal
China Medical Herald
Abstract
Objective: To study a good method of synthesize 3,4,5-trimethoxylbenzyl chloride.Methods: Used THF as solvent and 3,4,5-trimethoxylbenzene carbonic acid as the raw material,the 3,4,5-trimethoxylbenzyl chloride was prepared by an reduction action in ZnCl2/NaBH4 system,the acid translated into 3,4,5-trimethoxylbenzalcohol,and then by chlorination,the alcohol changed into 3,4,5-trimethoxylbenzyl chloride.Results: The target production was determined by IR and 1H-NMR spectrum.Conclusion: The 3,4,5-trimethoxylbenzyl chloride can be get by this process with high yield in mild condition.