Thi Ngoc Tram Huynh, P. Retailleau, C. Denhez
Jun 24, 2014
Citations
0
Influential Citations
12
Citations
Journal
Organic & biomolecular chemistry
Abstract
Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde. The cycloaddition regioselectivity is generally high (>95%) but decreases when an electron-rich substituent is located at the butynoate 4-position.