Shan Hou, Yuanzhang Zhou, W. Lu
Oct 15, 2016
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Abstract
3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile (1) is an important intermediate which used to synthesize NVP-BEZ-235 derivative. In this work, a rapid synthetic method for compound 1 was established. The 3-(4-aminophenyl) cyclopropane-1, 1, 2, 2-tetracarbonitrile was synthesized from the commercially available 4-nitrobenzaldehyde through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65.25% (caculated from malononitrile). KEYWORD: 2-(4-nitrobenzylidene)malononitrile; 3-(4-nitrophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; 3(4-aminophenyl)cyclopropane-1,1,2,2-tetracarbonitrile; Synthesis 4th International Conference on Mechanical Materials and Manufacturing Engineering (MMME 2016) © 2016. The authors Published by Atlantis Press 476 3 SYNTHESIS OF COMPOUNDS The structures and the synthetic route were shown in Scheme 1