Hiroshi Suzuki, Y. Kimura
Feb 4, 1992
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Journal
Journal of Fluorine Chemistry
Abstract
3,4-Difluorobenzonitrile has been prepared by a halogenexchange reaction between 3,4-dichlorobenzonitrile and spraydried potassium fluoride in the presence of tetraphenylphosphonium bromide in refluxing 1,3-dimethylimidazolidine-2one. In the fluorination reaction, 4-chloro-3-fluorobenzonitrile seems to be a key intermediate. 3,4-Difluorobenzonitrile, 2-, 3-, and 4-fluorobenzonitriles have also been produced from the corresponding chlorobenzonitrile derivatives by halogen-exchange at 290 'C in DMI in a pressure reactor.