Xubin Fang
2003
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Journal
Progress in Pharmaceutical Sciences
Abstract
[AIM] To investigate the synthesis of 3,4-dimethoxybenzylamine. [METHODS] Two routes for the synthesis of the target compound were devised. Route Ⅰ : Vanillin was chosen as the starting material to prepare the target compound via methylation, oxidation and reduction with Raney Nickel (Al/Ni Alloy); Route Ⅱ : 3, 4-Dimethoxybenzoic acid was chosen as the starting material to prepare the target compoud via chlorization, amidation and reduction with borohydride potassium. [RESULTS] The target compound was synthesized by the above routes, and its structure was confirmed by MS and 1HNMR. [CONCLUSION] Route Ⅰ , by which the target compound was obtained with 81. 7% overall yield, is suitable for industrial manufacture.