T. J. Connolly, M. Matchett, P. Mcgarry
Jun 15, 2004
Citations
1
Influential Citations
12
Citations
Journal
Organic Process Research & Development
Abstract
A streamlined, telescoped process has been developed for the preparation of 3,4-dimethoxy-o-toluic acid, starting with economical and readily available 2,3-dimethoxybenzaldehyde. Catalytic reduction of the aldehyde functional group generated dimethoxytoluene, which was brominated in situ. The resultant aryl bromide was isolated, converted into a Grignard reagent, and transformed into a carboxylic acid with dry ice. The process was demonstrated on a pilot-plant scale.