M. Dzieduszycka, S. Martelli, E. Borowski
Jan 12, 2009
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Journal
International Journal of Peptide and Protein Research
Abstract
3,4-Iminocyclohexyl-glycine and its N-benzyloxycarbonyl derivative were synthesized by the addition of iodine isocyanate to the double bond of properly protected 3-cyclohexenyl-glycine, followed by the conversion of addition product to a corresponding iodocarbamate and further cyclization to aziridine. 3,4-Iminocyclohexyl-glycine is the first representative of a novel group of amino acids analogs, aziridinoamino acids. The compound is glutamine analog and exhibits weak inhibitory activity in regard to glucosamine synthetase.