M. Alexy, H. Scharf
Dec 12, 1991
Citations
0
Influential Citations
7
Citations
Journal
European Journal of Organic Chemistry
Abstract
3,5-Dichloro-6-ethyl-2,4-dihydroxybenzoic acid (5, homodichloroorsellinic acid) is the polysubstituted aromatic carboxylic acid found in the macrolide antibiotic lipiarmycin A3. A convenient synthesis of the title compound from ethyl 2-pentenoate and ethyl acetoacetate is described (five steps, 41% overall yield).