L. Charon, J. Hoeffler, C. Pale-Grosdemange
Nov 26, 1999
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2- C -Methyl- d -erythritol 4-phosphate is a key intermediate in the mevalonate independent pathway for isoprenoid biosynthesis. In order to investigate the fate of the protons in this metabolic route, [3,5,5,5- 2 H 4 ]-2- C -methyl- d -erythritol was synthesized. The relevant steps allowing deuterium introduction were a palladium(II)-catalyzed hydrostannation and a coupling reaction between a vinyl iodide and a methylcyanocuprate.