Chen Bao-rong
2010
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Journal
Journal of Northwest University
Abstract
Aim To research the synthesis process of 3,5-dichloro-4-fluoro-trifluoro-toluene.Methods The title compound was synthesized from 3,4,5-dichloro-trifluoro-toluene and KF by phase transfer catalysis.Results Using TMSO2 as solvent,mole ratio n(3,4,5-trichlorobenzotrifluride)∶ n(KF)=1∶ 1.5,weight ratio m(PEG-600)∶ m(3,4,5-trichloro-benzotrifluoride)=0.5~0.7∶ 100,volume ratio V(3,4,5-trichlorobenzotrifluoride): V(TMSO2)=1∶ 3~3.5,stirring for 12h at 190~195℃,the conversion of 3,4,5-trichlorobenzotrifluoride is 87%,the yield is 80%,and the content is more than 98%.Conclusion The process was mild and available for synthesis of 3,5-dichloro-4-fluoro-trifluorotoluene.