Yang Shao-ji
2015
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Journal
Drugs and Clinic
Abstract
Objective To design and synthesize 3,6-bis(carboxymethyl)-4-amino-6H-thieno[2,3-b] pyrrole-2-carboxylic acid. Methods Citric acid was used as starting material to synthesize the target compound by oxidation, esterification, Gewald reaction, N-substituted, cyclization, hydrolysis, and decarboxylic reactions. Results The target compound was synthesized and characterized by MS and NMR data. And the purity detected by HPLC was 96.98%. The total recovery of the synthetic route was 2.7%. Conclusion The synthesis of 3,6-bis(carboxymethyl)-4-amino-6H-thieno[2,3-b]pyrrole-2-carboxylic acid provides convenience for the study of impurities in strontium ranelate.