Du Xiao-y
2015
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Journal
Chemical Reagents
Abstract
3,6-Dichlorosalicylic acid is a kind of important pesticide intermediate. It is also a key intermediate for production of herbicide dicamba. The route to synthesize the 3,6-dichlorosalicylic acid is determined. The cheap and easy gained 2,5-dichloronitrobenzene were choosed as initial raw materials. The intermediate 2,5-dichlorophenol was obtained via the hydrazine hydrate reduction and the diazotization reaction. Then the target product 3,6-dichlorosalicylic acid is obtained via carboxylation reaction by high temperature and pressure. The key reaction factors are investigated through single factor experiments,and optimum condition is obtained. The yield( calculated by 2,5-dichloronitrobenzene) and the purity of 3,6-dichlorosalicylic acid is 65. 8% and99. 24%,respectively,and quality satisfies the commercial requirement. The synthetic method is simple and economic,and the target product has high purity and easy separated. The structure of 3,6-dichlorosalicylic acid was confirmed via IR and1 HNMR.