Qian Zhang, Xiaobo Liu, Binliang Zhang
Jul 9, 2019
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IOP Conference Series: Earth and Environmental Science
Abstract
3, 8-dichloro-[1, 2, 4] triazolo [4, 3-a] pyrazine is an important intermediate for the synthesis of many small molecule anticancer drugs. It was synthesized from 2, 3-dichloropyrazine, N2H4• H2O (80%) and 2, 2, 2-trifluoroacetic anhydride through four steps including substitution, acylation, cyclization and chlorination reactions. The structure were confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the four steps were 76.57%.