Riccardo Surmont, G. Verniest, A. Weweire
Jul 1, 2009
Citations
0
Influential Citations
2
Citations
Journal
Synlett
Abstract
Fluorinated piperidines bearing an additional functional group at the heterocyclic ring are important building blocks for use in agrochemical or pharmaceutical chemistry. Therefore, for the first time 3-alkoxy-4,4-difluoropiperidines were synthesized by deoxofluorination of 3-alkoxy-4-piperidinones with morpholino-sulfur trifluoride and were selectively N- and O-deprotected. In addition, the oxidation of 4,4-difluoro-3,3-dihydroxypiperidine resulted in the interesting 4,4-difluoro-3,3-dihydroxypiperidine.