H. Ha, Y. Ahn, Gwan Sun Lee
Jun 18, 1999
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI-272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.