Clotilde Plaçais, Morgan Donnard, A. Panossian
Jun 3, 2021
Citations
0
Influential Citations
5
Citations
Journal
Organic letters
Abstract
A synthesis to access rarely described 3-amino-5-fluoroalkylfurans has been developed by cyclization of easily accessible fluorovinamides. This method is rapid and simple and affords the desired furans as hydrochloride salts in quantitative or nearly quantitative yields. It is compatible with four different fluorinated groups (-CF3, -CF2CF3, -CHF2, and -CF2Cl) and a wide range of substituents on the amine.