C. Jin
2006
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of New Drugs
Abstract
Objective :To synthesize 3-amino-6-methoxy-3,4-dihydro-2H-[1]benzopyran-4-one hydrochloride,an important intermediate of dopamine D3 receptor selective agonist PD128907.Methods: Starting from p-hydroxyanisole,3-amino-6-methoxy-3,4-dihydro-2H-[1]benzopyran-4-one hydrochloride was preparated by addition,hydrolysis,cyclization,oximation,esterification and Neber arrangement reac- tion.Results:The total yield was 43.4%.The structure has been confirmed by ~1HNMR,MS and IR.Con- clusion:The procedure has several advantages of cheap reagents,facile reaction conditions and high yield.