M. Girardin, P. Alsabeh, Sophie Lauzon
Feb 11, 2009
Citations
0
Influential Citations
27
Citations
Journal
Organic letters
Abstract
A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.