Y. Tominaga, Mayumi Hara, H. Honkawa
Jul 1, 1990
Citations
0
Influential Citations
9
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
N-Bis(methylthio)methylene-p-toluenesulfonamide (1) reacted with active methylene compounds such as malononitrile (2a) and, cyanoacetamide (2b) to give the corresponding 3-methylthio-3-p-toluenesulfonylami-nopropenenitrile derivatives 3a,b which were found to be convenient starting materials for the synthesis of 3,5-diaminopyrazole derivatives. Reaction of 3a and 3b with hydrazines gave the corresponding 3,5-diaminopyrazoles 4a-e, key intermediates for the synthesis of 3-aminopyrazolo[3,4-d]pyrimidine derivatives 5a-d.