L. Nunno, A. Scilimati
1987
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron
Abstract
Abstract By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n -butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1, 2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields. Treatment of such hydroxyisoxazolines with some common bases allows their conversion in high yields into the corresponding isoxazoles.