Jeong Mi Kim, Ka Young Lee, Jae Nyoung Kim
Dec 10, 2002
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Journal
ChemInform
Abstract
Seven-membered heterocycles with two heteroatoms in a 1,4-relationship are known to possess many biological activities. Particularly, aryl-annelated [1,4]diazepine and [1,4]oxazepine are crucial moieties in many psychoactive pharmaceuticals. 1,2 6-Benzylidene-oxazepane-5,7-dione is known as a valuable chiral intermediate. 3 Arylmethylene benzodiazepinones have been used for the synthesis of pesticidal pyrazolobenzodiazepines and thiazinobenzodiazepines. 4 Besides of these papers, numerous reports have been reported regarding the synthesis or biological activity of benzodiazepines 1 or dibenzodiazepines. 2 Recently, Reiser et al. have reported combinatorial liquid-phase synthesis of [1,4]oxazepin-7-ones via the Baylis-Hillman reaction. 5